Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac.

Abstract

The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P<0.001) and 2.3-fold (doxorubicin; P<0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.

• Authors: Thangirala Sudha, Dhruba J Bharali, Murat Yalcin, Noureldien He Darwish, Melis Debreli Coskun, Kelly A Keating, Hung-Yun Lin, Paul J Davis, Shaker A Mousa
• Journal: International journal of nanomedicine (Int J Nanomedicine) Vol. 12 Pg. 1305-1315 ( 2017) ISSN: 1178-2013 [Electronic] New Zealand
• PMID: 28243091 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polyglycolic Acid
• Lactic Acid
• Doxorubicin
• Paclitaxel
• tetraiodothyroacetic acid
• Thyroxine

Topics

• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Breast Neoplasms (drug therapy)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Doxorubicin (pharmacology, therapeutic use)
• Drug Delivery Systems
• Dynamic Light Scattering
• Female
• Humans
• Lactic Acid (chemistry)
• Mice, Nude
• Nanoparticles (chemistry)
• Paclitaxel (pharmacology, therapeutic use)
• Pancreatic Neoplasms (drug therapy)
• Particle Size
• Polyglycolic Acid (chemistry)
• Polylactic Acid-Polyglycolic Acid Copolymer
• Thyroxine (analogs & derivatives, chemistry)
• Xenograft Model Antitumor Assays