Beta-1,4-galactosyltransferase II predicts poor prognosis of patients with non-metastatic clear-cell renal cell carcinoma.

Abstract

Beta-1,4-galactosyltransferase II is found to be associated with the alterations of tumor-related glycosylation. However, the clinical significance of beta-1,4-galactosyltransferase II in non-metastatic clear-cell renal cell carcinoma has not been reported up to now. Herein, our researches suggested that the expression level of beta-1,4-galactosyltransferase II was first found to be positively associated with tumor size, Fuhrman grade, lymphovascular invasion, rhabdoid differentiation, tumor necrosis and poor overall survival and recurrence-free survival of patients with non-metastatic clear-cell renal cell carcinoma, both in training set and validation set. Moreover, beta-1,4-galactosyltransferase II expression was identified as an independent adverse prognosticator for overall survival and recurrence-free survival of patients with non-metastatic clear-cell renal cell carcinoma. Ultimately, prognostic accuracy of the nomogram integrating beta-1,4-galactosyltransferase II with other independent prognostic parameters was dramatically improved for overall survival and recurrence-free survival of patients with non-metastatic clear-cell renal cell carcinoma. Taken together, beta-1,4-galactosyltransferase II is a potential independent adverse prognostic factor for postoperative recurrence and survival, which could be developed as a useful biomarker for non-metastatic clear-cell renal cell carcinoma by a series of further independent and retrospective studies, so as to help the postsurgical management of clear-cell renal cell carcinoma patients.

• Authors: Haijian Zhang, Yidong Liu, Huyang Xie, Qiang Fu, Zheng Liu, Yu Zhu, Le Xu, Weijuan Zhang, Yuanfeng Yang, Jiejie Xu
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 39 Issue 2 Pg. 1010428317691417 (Feb 2017) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 28231735 (Publication Type: Journal Article)

Chemical References

• Galactosyltransferases
• beta-1,4-galactosyltransferase II

Topics

• Carcinoma, Renal Cell (enzymology, pathology)
• Galactosyltransferases (metabolism)
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Kidney Neoplasms (enzymology, pathology)
• Prognosis
• Retrospective Studies
• Tissue Array Analysis