Abstract | BACKGROUND: HYPOTHESIS: STUDY DESIGN: We evaluated endothelial function of rat pulmonary artery ex-vivo at the intermediate stage (4 weeks) of streptozotocin (STZ)-induced diabetes mellitus. We also evaluated the protective effect of grape seed extract administered daily, beginning the day after diabetes induction, or 15 days after diabetes induction, until the day of sacrifice. In addition, we compared the effect of grape seed extract supplementation with that of vitamin C. METHODS: Rats were made diabetic with streptozotocin (STZ, 65mg/kg i.v.). Thirty days later rats were sacrificed and pulmonary vessels reactivity and endothelial function compared to that of age-matched healthy animals. RESULTS: CONCLUSIONS: This study provides scientific support for the therapeutic potential of an antioxidant therapy in endothelial impairment associated with diabetes. A daily supplementation of grape seed proanthocyanidins and/or vitamin C given at the earlier stage of disease may have a complementary role in the pharmacological therapy of diabetes and pulmonary vascular dysfunction.
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Authors | Christian Pinna, Paolo Morazzoni, Angelo Sala |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 25
Pg. 39-44
(Feb 15 2017)
ISSN: 1618-095X [Electronic] Germany |
PMID | 28190469
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier GmbH. All rights reserved. |
Chemical References |
- Antioxidants
- Grape Seed Extract
- Grape Seed Proanthocyanidins
- Nitric Oxide Donors
- Proanthocyanidins
- Nitroprusside
- Ascorbic Acid
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Topics |
- Animals
- Antioxidants
(pharmacology, therapeutic use)
- Ascorbic Acid
(pharmacology)
- Diabetes Complications
(drug therapy, metabolism, pathology)
- Diabetes Mellitus, Experimental
(drug therapy, metabolism, pathology)
- Dietary Supplements
- Endothelium, Vascular
(drug effects, metabolism, pathology)
- Grape Seed Extract
(pharmacology, therapeutic use)
- Male
- Nitric Oxide Donors
(pharmacology)
- Nitroprusside
(pharmacology)
- Oxidative Stress
(drug effects)
- Phytotherapy
- Proanthocyanidins
(pharmacology, therapeutic use)
- Pulmonary Artery
(drug effects, metabolism, pathology)
- Rats, Sprague-Dawley
- Vasodilation
(drug effects)
- Vitis
(chemistry)
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