Serum N1-Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients.

Abstract

BACKGROUND:

We previously reported that serum N1-methylnicotinamide (me-Nam), an indicator of nicotinamide N-methyltransferase activity, is associated with obesity and diabetes mellitus in Chinese patients. However, whether nicotinamide N-methyltransferase plays a role in human coronary artery disease (CAD) remains to be elucidated. We aim to investigate the associations of serum me-Nam with CAD in Chinese patients.

METHODS AND RESULTS:

Serum me-NAM was measured by liquid chromatography-mass spectrometry in patients with (n=230) or without (n=103) CAD as defined by coronary angiography. The severity of CAD was expressed by number of diseased coronary arteries. Serum me-Nam was higher (7.65 ng/mL versus 4.95 ng/mL, P<0.001) in patients with CAD than in those without. Serum me-Nam was positively correlated with high-sensitivity C-reactive protein and negatively correlated with high-density lipoprotein before and after adjustment for potential confounding variables (P≤0.002). In multivariable logistic regression analyses, compared with those in the lowest tertile of serum me-NAM levels, patients in the top tertile had the highest risks for CAD (odds ratio, 4.21; 95% CI, 1.97-8.97 [P<0.001]). After adjustment for potential confounding variables, serum me-NAM was also increased from 0- to 3-vessel disease (P for trend=0.01).

CONCLUSIONS:

Serum me-Nam is strongly associated with presence and severity of CAD, suggesting nicotinamide N-methyltransferase as a potential target for treating atherosclerosis in humans.

• Authors: Ming Liu, Jihong Chu, Yang Gu, Haibo Shi, Rusheng Zhang, Lingzhun Wang, Jiandong Chen, Le Shen, Peng Yu, Xiaohu Chen, Wenzheng Ju, Zhenxing Wang
• Journal: Journal of the American Heart Association (J Am Heart Assoc) Vol. 6 Issue 2 (02 07 2017) ISSN: 2047-9980 [Electronic] England
• PMID: 28174167 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

Chemical References

• Biomarkers
• Niacinamide
• Nicotinamide N-Methyltransferase
• N(1)-methylnicotinamide

Topics

• Aged
• Biomarkers (blood)
• Body Mass Index
• China (epidemiology)
• Chromatography, Liquid (methods)
• Comorbidity
• Coronary Angiography (methods)
• Coronary Artery Disease (blood, diagnosis, epidemiology)
• Diabetes Mellitus (blood, epidemiology)
• Female
• Humans
• Male
• Mass Spectrometry (methods)
• Middle Aged
• Niacinamide (analogs & derivatives, blood)
• Nicotinamide N-Methyltransferase (blood)
• Obesity (blood, epidemiology)
• Reproducibility of Results
• Retrospective Studies
• Severity of Illness Index