A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?

Abstract

Background. The clinical and histopathologic classification of anetoderma are not well characterized. Objective. We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings. Methods. We retrospectively reviewed the medical records of 30 patients with anetoderma and performed immunohistochemistry for elastin, fibrillin-1, metalloproteinase- (MMP-) 2, MMP-7, MMP-9, and MMP-12, and tissue inhibitor of metalloproteinase- (TIMP-) 1 and TIMP-2. Results. Protruding type (n = 17) had a longer disease duration and more severe loss of elastin, without changes in fibrillin, than indented type (n = 13). MMP-2 and MMP-9 showed significantly higher expressions in the dermis compared with controls (p < 0.05). MMP-7 and MMP-12 showed little expressions in both anetoderma and control tissue. TIMP-1 was highly expressed in anetoderma lesions and controls. TIMP-2 expression was variable. Conclusions. Our findings suggest that protruding type anetoderma may represent a more advanced stage and that MMP-2 and MMP-9 could be responsible for elastic fiber degradation in anetoderma.

• Authors: Jung Eun Kim, Ki Min Sohn, Young Jun Woo, Kwan Ho Jeong, Miri Kim, Jeong Deuk Lee, Jun Young Lee, Hyun Jeong Park, Gyong Moon Kim, Chul Jong Park, Dong Soo Yu, Hoon Kang
• Journal: Journal of immunology research (J Immunol Res) Vol. 2016 Pg. 4325463 ( 2016) ISSN: 2314-7156 [Electronic] Egypt
• PMID: 28116317 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Fibrillin-1
• TIMP1 protein, human
• TIMP2 protein, human
• Tissue Inhibitor of Metalloproteinase-1
• Tissue Inhibitor of Metalloproteinase-2
• Elastin
• MMP7 protein, human
• Matrix Metalloproteinase 7
• MMP2 protein, human
• Matrix Metalloproteinase 2
• MMP9 protein, human
• Matrix Metalloproteinase 9
• MMP12 protein, human
• Matrix Metalloproteinase 12

Topics

• Adult
• Anetoderma (classification, immunology, pathology)
• Biomarkers (metabolism)
• Disease Progression
• Elastin (metabolism)
• Female
• Fibrillin-1 (metabolism)
• Humans
• Immunohistochemistry
• Male
• Matrix Metalloproteinase 12 (metabolism)
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 7 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Retrospective Studies
• Skin (pathology)
• Tissue Inhibitor of Metalloproteinase-1 (metabolism)
• Tissue Inhibitor of Metalloproteinase-2 (metabolism)
• Young Adult