Effect of Mifepristone on Corticosteroid Production in Vitro by Adrenal Glands of Rats with Streptozotocin Diabetes.

Abstract

Changes in pregnenolone and corticosterone production by the adrenal glands of normoglycemic rats receiving the course of intraperitoneal mifepristone or NaCl administration were co-directed, but differed in magnitude. In rats with hyperglycemia, corticosteroid production increased after NaCl administration over 5 days and returned to the initial values after 15-day administration. On the contrary, pregnenolone and corticosterone production was suppressed after 5-day course of mifepristone, but significantly increased after mifepristone administration for 15 days. Intraperitoneal mifepristone administration almost completely abolished the response of rat adrenal glands with normo- and hyperglycemia to ACTH in vitro; this effect did not depend on the duration of administration.

• Authors: N V Kuznetsova, N A Palchikova, V G Selyatitskaya, O I Kuzminova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 162 Issue 3 Pg. 327-330 (Jan 2017) ISSN: 1573-8221 [Electronic] United States
• PMID: 28091906 (Publication Type: Journal Article)

Chemical References

• Hormone Antagonists
• Mifepristone
• Sodium Chloride
• Streptozocin
• Pregnenolone
• Adrenocorticotropic Hormone
• Corticosterone

Topics

• Adrenal Glands (drug effects, metabolism, pathology)
• Adrenocorticotropic Hormone (pharmacology)
• Animals
• Corticosterone (biosynthesis)
• Diabetes Mellitus, Experimental (chemically induced, metabolism, pathology)
• Hormone Antagonists (pharmacology)
• Hyperglycemia (chemically induced, metabolism, pathology)
• Injections, Intraperitoneal
• Male
• Mifepristone (pharmacology)
• Organ Culture Techniques
• Pregnenolone (biosynthesis)
• Rats
• Rats, Wistar
• Sodium Chloride (pharmacology)
• Streptozocin