Assessment of Carotid Plaque Inflammation in Diabetic and Nondiabetic Patients-An Exploratory Ultrasmall Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging Study.

Abstract

BACKGROUND:

Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance (MR) imaging enables the identification of inflammation within the atheroma, predominantly by USPIO uptake by macrophages present in atherosclerotic tissue. Diabetic patients, however, may have dysfunctional macrophage activity, which may affect utilization of USPIO in identifying plaque inflammation in this patient cohort.

METHODS:

Fifteen diabetic and fifteen nondiabetic patients underwent USPIO-enhanced carotid MR imaging using 1.5T MR system. Pre- and post-USPIO carotid MR images were manually coregistered. The percentage decrease in the signal intensity after USPIO administration was calculated as a relative measure of the USPIO uptake.

RESULTS:

Diabetic and nondiabetic patients had comparable demographics and comorbidities. The mean global, maximum quadrant, and maximum slice changes showing change in relative signal intensity as a result of USPIO administration were comparable for the two patient cohorts (P > .05).

CONCLUSIONS:

USPIO can identify inflammatory burden with carotid atheroma in both diabetic and nondiabetic patients.

• Authors: Ammara Usman, Andrew J Patterson, Umar Sadat, Tjun Y Tang, Martin J Graves, Jonathan H Gillard
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 26 Issue 4 Pg. 858-862 (Apr 2017) ISSN: 1532-8511 [Electronic] United States
• PMID: 27881291 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Dextrans
• Magnetite Nanoparticles
• ferumoxtran-10

Topics

• Aged
• Carotid Stenosis (diagnostic imaging, etiology)
• Dextrans (metabolism)
• Diabetes Mellitus (physiopathology)
• Electrocardiography
• Female
• Humans
• Image Processing, Computer-Assisted
• Inflammation (diagnostic imaging, etiology)
• Magnetic Resonance Angiography
• Magnetic Resonance Imaging
• Magnetite Nanoparticles
• Male
• Middle Aged
• Statistics, Nonparametric