Altered uterine contractility in response to β-adrenoceptor agonists in ovarian cancer.

Abstract

We aimed to prospectively examine β-adrenoceptor-mediated uterine contractility in women suffering from gynecological malignancies. Myometrial specimens were obtained from non-pregnant women undergoing hysterectomy for benign gynecological disorders, and ovarian, endometrial, synchronous ovarian-endometrial, and cervical cancer. Contractions of myometrial strips in an organ bath before and after cumulative dosages of β2- and β3-adrenoceptor agonists with preincubation of propranolol, SR 59230A, and butoxamine were studied. All agonists induced a dose-dependent attenuation for uterine contractility in endometrial or cervical cancer, similar to that observed in the reference group. Contradictory effects were observed for ovarian cancer alone or in combination with endometrial cancer. CL 316243 or ritodrine abolished the relaxation, whereas BRL 37344 increased the uterine contractility in ovarian cancer. Moreover, β-adrenoceptor antagonists caused varied effects for β2- or β3-adrenoceptor agonists. Our experiments demonstrate that ovarian cancer, alone or as synchronous ovarian-endometrial cancer, substantially alters uterine contractility in response to β-adrenoceptor agonists.

• Authors: Beata Modzelewska, Maciej Jóźwik, Marcin Jóźwik, Stanisław Sulkowski, Anna Pędzińska-Betiuk, Tomasz Kleszczewski, Anna Kostrzewska
• Journal: The journal of physiological sciences : JPS (J Physiol Sci) Vol. 67 Issue 6 Pg. 711-722 (Nov 2017) ISSN: 1880-6562 [Electronic] Japan
• PMID: 27838886 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-3 Receptor Agonists
• Adrenergic beta-Agonists
• Dioxoles
• Ethanolamines
• Receptors, Adrenergic, beta
• disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate
• BRL 37344
• Ritodrine

Topics

• Adrenergic beta-3 Receptor Agonists (pharmacology)
• Adrenergic beta-Agonists (pharmacology)
• Adult
• Aged
• Aged, 80 and over
• Dioxoles (pharmacology)
• Endometrial Neoplasms
• Ethanolamines (pharmacology)
• Female
• Humans
• Middle Aged
• Ovarian Neoplasms
• Receptors, Adrenergic, beta (physiology)
• Ritodrine (pharmacology)
• Uterine Contraction (drug effects, physiology)