Tetanus in Southern Vietnam: Current Situation.

Abstract

In Vietnam, there are no accurate data on tetanus incidence to allow assessment of disease burden or vaccination program efficacy. We analyzed age structure of 786 tetanus cases admitted to a tertiary referral center in Vietnam for three separate years during an 18-year period to examine the impact of tetanus prevention programs, namely the Expanded Program on Immunization (EPI) and the Maternal and Neonatal Tetanus (MNT) initiative. Most cases were born before the initiation of EPI. Median age increased from 33 (interquartile range: 20-52) in 1994, to 46 (32-63) in 2012 (P < 0.001). Birth-year distribution was unchanged, indicating the same birth cohorts presented with tetanus in 1994, 2003, and 2012. Enzyme-linked immunosorbent assay measurements in 90 men and 90 women covered by MNT but not EPI showed 73.3% (95% confidence interval [CI]: 62.9-82.1%) of women had anti-tetanus antibody compared with 24.4% (95% CI: 15.9-34.7%) of men, indicating continued tetanus vulnerability in older men in Vietnam.

• Authors: Duong Bich Thuy, James I Campbell, Tran Tan Thanh, Cao Thu Thuy, Huynh Thi Loan, Nguyen Van Hao, Yen Lam Minh, Le Van Tan, Maciej F Boni, C Louise Thwaites
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 96 Issue 1 Pg. 93-96 (Jan 11 2017) ISSN: 1476-1645 [Electronic] United States
• PMID: 27821690 (Publication Type: Journal Article)
• Copyright: © The American Society of Tropical Medicine and Hygiene.

Chemical References

• Tetanus Toxoid

Topics

• Adult
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Middle Aged
• Public Health Administration
• Tetanus (epidemiology, prevention & control)
• Tetanus Toxoid (administration & dosage, immunology)
• Vaccination
• Vietnam (epidemiology)
• Young Adult