Postrehabilitation Functional Improvements in Patients With Inflammatory Myopathies: The Results of a Randomized Controlled Trial.

Abstract

OBJECTIVE:

To evaluate the medium-term functional effect and the effect on quality of life of a standardized rehabilitation program in patients with inflammatory myopathies (IMs).

DESIGN:

A multicenter, randomized controlled trial.

SETTING:

Four university hospitals.

PARTICIPANTS:

Patients (N=21) with polymyositis.

INTERVENTIONS:

The intervention group participated in a 4-week standardized, hospital-based rehabilitation program followed by a personalized, self-managed, home-based rehabilitation program. The control group received physiotherapy on an outpatient basis. Study participants were evaluated at inclusion, at the end of the rehabilitation program (1mo), and then at 6 and 12 months.

MAIN OUTCOME MEASURES:

The primary efficacy criterion was the Health Assessment Questionnaire Disability Index (HAQ-DI), and the secondary criteria were quality of life (according to the Medical Outcomes Study 36-Item Short-Form Health Survey [SF-36] questionnaire), muscle performance (isokinetic strength, Motor Function Measure, and Kendall Manual Muscle Test), gait, pain, fatigue, and biomarkers of tolerance and disease activity.

RESULTS:

At 12 months, the mean ± SD HAQ-DI was significantly lower in the intervention group than in the control group (.64±.53 vs 1.36±1.02; P=.026). The intervention group also had better scores than the control group for some quality-of-life dimensions (SF-36 General Health: 53.44±8.73 vs 36.57±22.10, respectively; P=.038; SF-36 Role Physical: 63.89±43.50 vs 17.86±37.40, respectively; P=.023) and pain levels (5.0±10.61 vs 33.38±35.68, respectively; P=.04) at 12 months. The program was well tolerated by all the participants.

CONCLUSIONS:

In patients with IMs, the combination of a 4-week standardized rehabilitation program and a personalized, home-based, self-managed rehabilitation program was well tolerated and had a positive medium-term functional effect.

• Authors: Vincent Tiffreau, François Rannou, François Kopciuch, Eric Hachulla, Luc Mouthon, Philippe Thoumie, Jean Sibilia, Elodie Drumez, André Thevenon
• Journal: Archives of physical medicine and rehabilitation (Arch Phys Med Rehabil) Vol. 98 Issue 2 Pg. 227-234 (02 2017) ISSN: 1532-821X [Electronic] United States
• PMID: 27789240 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers

Topics

• Adult
• Biomarkers
• Cardiorespiratory Fitness (physiology)
• Disability Evaluation
• Exercise Therapy
• Female
• Health Status
• Hospitals, University
• Humans
• Male
• Middle Aged
• Muscle, Skeletal (physiology)
• Myositis (rehabilitation)
• Pain (rehabilitation)
• Physical Therapy Modalities
• Quality of Life
• Range of Motion, Articular