Abstract |
Heart transplantation (HT) recipients may have tachycardia secondary to cardiac denervation. As higher heart rate predicts worse outcomes in cardiovascular disease, we hypothesized that tachycardia and nonuse of β blockers are associated with increased mortality after HT. All patients who underwent HT at our institution from 1987 to 2010 were included. The association of heart rate 3 months after HT and β-blocker use during follow-up to mortality was assessed using Kaplan-Meier and multivariate Cox proportional hazards regression analyses adjusting for clinically relevant baseline variables. From 1987 to 2010, there were 493 HT. After excluding 29 who died within 3 months and 3 with follow-up <3 months, 461 HT recipients (50 ± 2 years; 20% women) were included. Over a follow-up of 12 ± 7 years, selected important univariate predictors of post-HT mortality were older age, male gender, higher body mass index, ischemic cardiomyopathy, longer post-HT intensive care unit stay, and hospitalization and at 3 months, increased mean pulmonary artery pressure, right atrial pressure and pulmonary capillary occlusion pressure, higher heart rate, and nonuse of β blockers during follow-up. In multivariate analysis, older ager, longer hospitalization, higher mean pulmonary artery pressure, higher heart rate at 3 months (hazard ratio 1.02 per beat, 95% confidence interval 1.008 to 1.035, p = 0.02) and nonuse of β blockers (hazard ratio 1.43, 95% confidence interval 1.002 to 2.031, p <0.05) were associated with mortality. In conclusion, in a large single-center cohort of HT recipients, higher heart rate and nonuse of β blockers were independently associated with higher mortality.
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Authors | Agnieszka Ciarka, Lars H Lund, Johan Van Cleemput, Gabor Voros, Walter Droogne, Johan Vanhaecke |
Journal | The American journal of cardiology
(Am J Cardiol)
Vol. 118
Issue 12
Pg. 1916-1921
(Dec 15 2016)
ISSN: 1879-1913 [Electronic] United States |
PMID | 27743576
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Chemical References |
- Adrenergic beta-Antagonists
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Adult
- Age Factors
- Blood Preservation
- Cardiomyopathy, Dilated
(surgery)
- Cohort Studies
- Female
- Heart Rate
- Heart Transplantation
- Humans
- Intensive Care Units
- Kaplan-Meier Estimate
- Length of Stay
- Male
- Middle Aged
- Mortality
- Multivariate Analysis
- Myocardial Ischemia
(epidemiology, surgery)
- Proportional Hazards Models
- Protective Factors
- Pulmonary Wedge Pressure
- Retrospective Studies
- Sex Factors
- Treatment Outcome
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