Asymmetric dimethylarginine and arterial stiffness in patients with rheumatoid arthritis: A case-control study.

Abstract

OBJECTIVE:

To investigate whether levels of asymmetric dimethylarginine (ADMA), as a measure of endothelial dysfunction, are higher in patients with rheumatoid arthritis compared with healthy control subjects. The relationships between ADMA and surrogate measures of arterial stiffness were evaluated.

METHODS:

Patients with rheumatoid arthritis and healthy control subjects were recruited. ADMA was quantified via enzyme-linked immunosorbent assay. Arterial stiffness was evaluated using pulse wave analysis.

RESULTS:

There was no significant difference in plasma ADMA concentration between patients with rheumatoid arthritis (n = 30) and healthy controls (n = 30). Aortic augmentation pressure was significantly higher in patients than in controls. C-reactive protein and Health Assessment Questionnaire score were independent predictors of arterial stiffness in patients. There was no relationship between ADMA concentration and aortic augmentation pressure in the study population as a whole.

CONCLUSIONS:

Arterial stiffness appears to be increased in rheumatoid arthritis and independently associated with systemic inflammation and physical disability. ADMA concentration was not increased in this small group of patients with rheumatoid arthritis compared with healthy controls; nor was it associated with arterial stiffness.

• Authors: Gian Luca Erre, Alessandra Piras, Silvia Mura, Nicola Mundula, Marco Piras, Loredana Taras, Maria Giovanna Longu, Pier Sergio Saba, Antonello Ganau, Ciriaco Carru, Giuseppe Passiu
• Journal: The Journal of international medical research (J Int Med Res) Vol. 44 Issue 1 suppl Pg. 76-80 (Sep 2016) ISSN: 1473-2300 [Electronic] England
• PMID: 27683145 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2016.