The correlation between FDG uptake and biological molecular markers in pancreatic cancer patients.

Abstract

PURPOSE:

We examined whether fluorine-18 fluorodeoxyglucose (FDG) uptake is related to the mammalian target of rapamycin (mTOR) signal pathway and its related proteins in pancreatic cancer patients.

METHODS:

We retrospectively studied 53 pancreatic cancer patients who underwent FDG positron emission tomography (PET) or FDG PET/CT, and complete curative surgical resection. The SUV max, the tumor to nontumor activity of pancreas [T/N (P)] ratio and the T/N of liver [T/N (L)] ratio were calculated. The expressions of glucose transporter-1(Glut-1) and mTOR pathway proteins in pancreas cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry using monoclonal antibodies for Glut-1, epidermal growth factor receptor (EGFR), mTOR, p70S6kinase (p70S6) and S6 ribosomal protein (S6).

RESULTS:

The expressions of Glut-1, EGFR and p70S6 were significantly correlated with the SUV max, T/N (P) ratio and T/N (L) ratio. The expressions of mTOR and S6 were not correlated with all parameters. The expression of Glut-1 was positively correlated with the expressions of EGFR and p70S6, but not with mTOR or S6. S6 was positively correlated with p70S6.

CONCLUSIONS:

Glut-1, EGFR and p70S6 expressions are associated with the FDG uptake mechanism of pancreatic cancer. FDG uptake may predict the levels of EGFR and p70S6 expressions, and FDG uptake reflects glucose metabolism and cancer progression.

• Authors: Hayato Kaida, Koichi Azuma, Akihiko Kawahara, Masafumi Yasunaga, Yuhei Kitasato, Satoshi Hattori, Tomoki Taira, Hiroki Ureshino, Masayoshi Kage, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
• Journal: European journal of radiology (Eur J Radiol) Vol. 85 Issue 10 Pg. 1804-1810 (Oct 2016) ISSN: 1872-7727 [Electronic] Ireland
• PMID: 27666620 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Glucose Transporter Type 1
• Radiopharmaceuticals
• SLC2A1 protein, human
• Fluorodeoxyglucose F18
• MTOR protein, human
• EGFR protein, human
• ErbB Receptors
• TOR Serine-Threonine Kinases

Topics

• Aged
• Aged, 80 and over
• Animals
• Cells, Cultured
• ErbB Receptors (metabolism)
• Female
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Glucose Transporter Type 1 (metabolism)
• Humans
• Immunohistochemistry
• Japan (epidemiology)
• Male
• Middle Aged
• Pancreatic Neoplasms (diagnostic imaging, epidemiology, pathology)
• Positron Emission Tomography Computed Tomography
• Preoperative Care
• Radiopharmaceuticals (pharmacokinetics)
• Retrospective Studies
• TOR Serine-Threonine Kinases (metabolism)