Standard and double-dose intravenous proton pump inhibitor injections for prevention of bleeding after endoscopic resection.

Abstract

BACKGROUND AND AIM:

Endoscopic resection is commonly used to remove gastric neoplasms. However, effective dosing or scheduling of proton pump inhibitors for the prevention of delayed bleeding after endoscopic resection remains unclear.

METHODS:

One hundred sixty-six patients with gastric adenoma or early gastric cancer were enrolled. After an endoscopic procedure, each subject was randomly assigned to 40 mg every 24 h (standard dose group) or 40 mg every 12 h (double-dose group) of intravenous pantoprazole for 48 h. Second-look endoscopy was performed on day 2 after endoscopic resection to compare signs of rebleeding and ulcer status between the two groups.

RESULT:

Eighty-one patients of the standard dose group and 81 of the double-dose group were analyzed. There were no significant differences in the incidence of delayed bleeding events (1.3% vs 6.2%, P = 0.21) and bleeding ulcer at the second-look endoscopy (6.2% vs 3.9%, P = 0.69) between standard and double-dose groups. There were no other significant variables associated with delayed bleeding or bleeding ulcer on second-look endoscopy.

CONCLUSIONS:

Intravenous pantoprazole 40 mg every 24 h or 12 h for 2 days after endoscopic resection was equally effective for the prevention of delayed bleeding.

• Authors: Sung Woo Jung, Seung Young Kim, Jung Wan Choe, Jong Jin Hyun, Young Kul Jung, Ja Seol Koo, Hyung Joon Yim, Sang Woo Lee
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 32 Issue 4 Pg. 778-781 (Apr 2017) ISSN: 1440-1746 [Electronic] Australia
• PMID: 27637734 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Proton Pump Inhibitors
• Pantoprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles (administration & dosage)
• Adenoma (surgery)
• Aged
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Endoscopy, Gastrointestinal
• Female
• Gastrointestinal Hemorrhage (prevention & control)
• Humans
• Infusions, Intravenous
• Male
• Middle Aged
• Pantoprazole
• Postoperative Complications (prevention & control)
• Prospective Studies
• Proton Pump Inhibitors (administration & dosage)
• Reoperation
• Stomach Neoplasms (surgery)
• Time Factors
• Treatment Outcome