Abstract | BACKGROUND: OBJECTIVE: We investigated whether visual ratings of posterior atrophy (PA) on magnetic resonance imaging show independent predictive value for the progression to dementia in MCI patients. METHODS: This was a retrospective cohort study of elderly patients who visited Seoul National University Bundang Hospital between 2004 and 2012. A total of 148 patients who were initially diagnosed with MCI were followed for up to 3 years (median 22 months) to determine whether they progressed to dementia. We used 4-point and 5-point visual rating scales to assess PA and MTA, respectively. PA and MTA scores were dichotomized into normal (no atrophy) or abnormal ( atrophy) in each patient. We performed a Cox regression analysis to examine the hazard ratios (HRs) of PA and MTA for the progression to dementia with adjustment for age, APOEɛ4 allele status, and baseline Mini-Mental State Examination score. RESULTS: Among the study population, 47 patients progressed to dementia. Visual assessment of the MRI scans revealed that 67 patients (45.3%) showed PA, whereas 85 patients (57.3%) showed MTA. The HRs with 95% confidence intervals for PA and MTA were 2.516 (1.244-5.091) and 4.238 (1.680-10.687), respectively. The predictive values of visually assessed PA and MTA remained significant, independent of the covariates. CONCLUSION: Visual assessment of PA has independent predictive value for progression to dementia in MCI patients.
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Authors | Hang-Rai Kim, Young Ho Park, Jae-Won Jang, So Young Park, Min Jeong Wang, Min Jae Baek, Beom Joon Kim, Soyeon Ahn, SangYun Kim |
Journal | Journal of Alzheimer's disease : JAD
(J Alzheimers Dis)
Vol. 55
Issue 1
Pg. 137-146
( 2017)
ISSN: 1875-8908 [Electronic] Netherlands |
PMID | 27636842
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Age Factors
- Aged
- Aged, 80 and over
- Apolipoprotein E4
(genetics)
- Atrophy
- Brain
(diagnostic imaging)
- Cognitive Dysfunction
(diagnostic imaging, genetics, physiopathology)
- Dementia
(diagnostic imaging, genetics, physiopathology)
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Magnetic Resonance Imaging
- Male
- Mental Status and Dementia Tests
- Middle Aged
- Proportional Hazards Models
- Retrospective Studies
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