Renoprotection and Mechanisms of Erythropoietin and Its Derivatives Helix B Surface Peptide in Kidney Injuries.

Abstract

The renoprotection of erythropoietin (EPO) and its derivatives such as helix B surface peptide (HBSP) have attracted a great deal of attention from scientists and clinicians alike. The evolutional achievement in the dissociation of tissue protection and erythropoiesis is obtained through HBSP characterisation and synthesis. We performed a series of studies using EPO, as well as HBSP, in a variety of biological models subjected to transplant-related renal injuries such as ischemia reperfusion injury (IRI) and/or immunosuppressant nephrotoxicity. In this short review, we would like to address the effects of EPO in different formats, and its underlying mechanisms with focuses on apoptosis and inflammation in in vitro, ex vivo and in vivo renal injury models, and to further explore potential applications and challenges in humans.

• Authors: Yufang Zhang, Weiwei Chen, Yuanyuan Wu, Bin Yang
• Journal: Current protein & peptide science (Curr Protein Pept Sci) Vol. 18 Issue 12 Pg. 1183-1190 ( 2017) ISSN: 1875-5550 [Electronic] United Arab Emirates
• PMID: 27634442 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Anti-Inflammatory Agents
• Cytokine Receptor Common beta Subunit
• EPO protein, human
• Peptide Fragments
• Protective Agents
• Receptors, Erythropoietin
• glutaminyl-glutamyl-glutaminyl-leucyl-glutamyl-arginyl-alanyl-leucyl-asparagyl-seryl-serine
• Erythropoietin

Topics

• Acute Kidney Injury (drug therapy, genetics, metabolism, pathology)
• Animals
• Anti-Inflammatory Agents (pharmacology)
• Apoptosis (drug effects)
• Cytokine Receptor Common beta Subunit (genetics, metabolism)
• Disease Models, Animal
• Erythropoietin (pharmacology)
• Gene Expression Regulation
• Humans
• Kidney (drug effects, metabolism, pathology)
• Oxidative Stress (drug effects)
• Peptide Fragments (pharmacology)
• Protective Agents (pharmacology)
• Receptors, Erythropoietin (genetics, metabolism)
• Reperfusion Injury (drug therapy, genetics, metabolism, pathology)