Abstract |
Teicoplanin, a glycopeptide antibiotic for methicillin-resistant Staphylococcus aureus, is recommended for therapeutic drug monitoring during treatment. Maintaining a high trough range of teicoplanin is also recommended for severe infectious disease. However, the optimal dose and interval of treatment for severe renal impairment is unknown. We report a 79-year-old man who received long-term teicoplanin treatment for methicillin-resistant Staphylococcus aureus bacteremia due to postoperative sternal osteomyelitis with renal impairment. Plasma teicoplanin trough levels were maintained at a high range (20-30 μg/mL). Although the patient required long-term teicoplanin treatment, a further decline in renal function was not observed, and blood culture remained negative after the start of treatment. Teicoplanin treatment that is maintained at a high trough level by therapeutic drug monitoring might be beneficial for severe methicillin-resistant Staphylococcus aureus infection accompanied by renal impairment.
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Authors | Hideo Shiohira, Masashi Nakamatsu, Yuya Kise, Futoshi Higa, Masao Tateyama, Nobuo Hokama, Yukio Kuniyoshi, Shinichiro Ueda, Katsunori Nakamura, Jiro Fujita |
Journal | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
(Yakugaku Zasshi)
Vol. 136
Issue 9
Pg. 1313-7
( 2016)
ISSN: 1347-5231 [Electronic] Japan |
PMID | 27592834
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Aged
- Drug Monitoring
- Humans
- Male
- Methicillin-Resistant Staphylococcus aureus
- Osteomyelitis
(complications, drug therapy, microbiology)
- Postoperative Complications
- Renal Insufficiency
(complications)
- Severity of Illness Index
- Staphylococcal Infections
- Sternum
- Teicoplanin
(administration & dosage, blood)
- Time Factors
- Treatment Outcome
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