Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea.

Abstract

PURPOSE:

Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy.

METHODS:

Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups: group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis).

RESULTS:

After peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries.

CONCLUSIONS:

Ara h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy.

• Authors: Kyung Hee Park, Young Woong Son, Sang Chul Lee, Kyunguk Jeong, Da Woon Sim, Hye Jung Park, Sooyoung Lee, Jae Hyun Lee, Jung Won Park
• Journal: Allergy, asthma & immunology research (Allergy Asthma Immunol Res) Vol. 8 Issue 6 Pg. 505-11 (Nov 2016) ISSN: 2092-7355 [Print] Korea (South)
• PMID: 27582401 (Publication Type: Journal Article)