Abstract | AIMS: A recent review of archived sections from early experiments in rats showed neoplasias exhibiting serrated configurations. The aim was to assess the frequency of serrated neoplasias in the colon and small intestine of carcinogen-treated rats. METHODS: While reviewing archival sections from early experiments in Sprague-Dawley (SD) and Fisher-344 (F-344) rats, we recently detected colonic and intestinal traditional serrated adenomas (displaying serrated or microtubular patterns) and serrated carcinomas. SD rats were injected 1,2-dimethylhydrazine ( DMH) for 27 weeks whereas F-344 rats were fed with a pyrolysate (GLU-1) for 24 months. Filed sections from 358 colonic and small intestinal neoplasias were re-evaluated. RESULTS: CONCLUSIONS:
DMH/SD-rats develop serrated and microtubular adenomas and carcinomas in the colon, whereas GLU1/F-344 rats develop microtubular adenomas in the colon and microtubular adenomas and carcinomas in the small intestine. The two rat-settings emerge as suitable models to study the molecular attributes of serrated and microtubular neoplasias under the standard conditions of the laboratory. This study is the first showing that a substantial number of serrated and particularly microtubular adenomas and carcinomas develop in the colon and small intestine of experimental rats. Importantly, serrated and microtubular neoplasias in rats recreate the histology of duodenal and colonic traditional serrated neoplasias in human beings.
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Authors | Carlos A Rubio |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 70
Issue 4
Pg. 301-307
(Apr 2017)
ISSN: 1472-4146 [Electronic] England |
PMID | 27566816
(Publication Type: Journal Article)
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Copyright | Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. |
Chemical References |
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Topics |
- Adenocarcinoma
(chemically induced, pathology)
- Adenoma
(chemically induced, pathology)
- Animals
- Carcinogens
(toxicity)
- Colorectal Neoplasms
(chemically induced, pathology)
- Disease Models, Animal
- Rats
- Rats, Inbred F344
- Rats, Sprague-Dawley
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