1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)

12/01/2013 - "These two cured meats were thus given to rats pretreated with 1,2-dimethylhydrazine, to evaluate their effect on colorectal carcinogenesis. "
06/18/2010 - "FD provided protection against tumorigenesis in a BER-deficient environment in all tissues where 1,2-dimethylhydrazine exerts its damage. "
11/01/2020 - "The studies show a great diversity of models, most were conducted in rats (55.8%) and used 1,2 dimethylhydrazine as the drug to induce colorectal carcinogenesis (61.7%). "
11/01/2014 - "Synbiotic (Lactobacillus rhamnosus+Lactobacillus acidophilus+inulin) attenuates oxidative stress and colonic damage in 1,2 dimethylhydrazine dihydrochloride-induced colon carcinogenesis in Sprague-Dawley rats: a long-term study."
08/01/1993 - "[A histogenetic study on the carcinogenesis of colonic mucous membrane glands induced by 1,2-dimethylhydrazine in rats]."

08/06/2021 - "The present research aimed to formulate a natural fiber-rich food product (NFRFP) and to evaluate its safety, toxicogenetics, and effects on aberrant crypt foci induced by 1,2-dimethyl-hydrazine in a preclinical model. "
12/01/2005 - "The number of colorectal aberrant crypt foci (ACF), putative preneoplastic lesions induced by 1,2-dimethylhydrazine, was reduced after MDT-1 administration (10(9) cfu/dose, 3 times/wk for 4 wk). "
01/01/2000 - "Inhibition by ginseng of 1,2-dimethylhydrazine induction of aberrant crypt foci in the rat colon."
11/01/1997 - "Inhibition of development of N,N'-dimethylhydrazine-induced rat colonic aberrant crypt foci by pre, post and simultaneous treatments with 24R,25-dihydroxyvitamin D3."
02/26/1997 - "Specific species of intestinal bacteria influence the induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats."

08/01/2005 - "Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer."
11/01/1997 - "In the present study, colon adenocarcinomas were induced by 1,2-dimethylhydrazine treatment in rats. "
11/01/1992 - "In a series of experiments, we used the 1,2-dimethylhydrazine animal model of colonic cancer in conjunction with these drugs, to study the effect on the development of colon cancer. "
10/01/2023 - "1,2 dimethylhydrazine (25 mg/kg, sc) was used for colon cancer induction. "
09/27/2023 - "Colon cancer was induced by injecting 1,2-dimethylhydrazine (25 mg/kg, sc) twice a week. "

01/01/2007 - "In another study in rats, however, red chile pepper in the diet at the same dose decreased the number of tumors seen with 1,2-dimethylhydrazine. "
07/15/1986 - "Gut-associated lymphoid tissue and 1,2-dimethylhydrazine intestinal tumors in the rat: an histological and immunoenzymatic study."
03/01/1978 - "A 1,2-dimethylhydrazine dihydrochloride-induced rat gastrointestinal tract tumor model was used to study the phenomenon of immunologic surveillance. "
11/15/2019 - "For tumor induction 20 mg/kg of 1,2-dimethylhydrazine was applied intraperitoneally over 4 weeks, followed by an interval of 15 days, and then repeated for a further 4 weeks. "
04/01/2006 - "We showed previously that CLA reduced the incidence of colon tumors in rats treated with 1,2-dimethylhydrazine. "

03/09/2023 - "The Potential Chemopreventive Effect of Andrographis paniculata on 1,2-Dimethylhydrazine and High-Fat-Diet-Induced Colorectal Cancer in Sprague Dawley Rats."
10/01/2010 - "Early stages of colorectal cancer were produced in rats with 1,2-dimethylhydrazine dihydrochloride. "
06/01/2003 - "High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine."
03/01/2001 - "Effect of bacterial metabolism in the intestine on colorectal tumors induced by 1,2-dimethylhydrazine in transgenic mice harboring human prototype c-Ha-ras genes."
04/01/1998 - "Effect of mouse intestinal bacteria on incidence of colorectal tumors induced by 1,2-dimethylhydrazine injection in gnotobiotic transgenic mice harboring human prototype c-Ha-ras genes."