Improved diastolic function in type 2 diabetes after a six month liraglutide treatment.

Abstract

AIMS:

To investigate whether liraglutide improves diastolic function in type 2 diabetes.

METHODS:

Thirty-seven patients with type 2 diabetes who began liraglutide therapy between June 2013 and May 2014 were enrolled in this observational, prospective study. 26 patients received liraglutide therapy for at least 6months. The remaining 11 patients withdrew from liraglutide therapy during the first month, were started on other hypoglycaemic therapies and formed the control group. Anthropometric, metabolic and echocardiographic parameters including pulsed wave tissue Doppler imaging were evaluated at baseline and at 6months.

RESULTS:

In the liraglutide group the early diastolic mitral annulus velocity on the lateral (e-lat) and medial (e-med) sides of the mitral annulus increased from 9.2±3.4 to 11.6±4.7cm/s (p<0.001) and from 6.9±1.7 to 8.4±2.6cm/s (p<0.003), respectively. The ratio of early-to-late velocities on the lateral and medial sides of the mitral annulus increased from 0.7±0.3 to 0.9±0.4 (p<0.001) and from 0.5±0.1 to 0.6±0.1 (p<0.02), respectively. The ratio of early diastolic mitral inflow velocity to early diastolic myocardial relaxation velocity decreased from 10.7±4.3 to 8.5±2.5 (p<0.005). No improvements in diastolic function was detected in the control group. Glucose control improved similarly in both groups: HA1bc -1.5% (-17mmol/mol) vs -1.3% (-14mmol/mol), p=0.67.

CONCLUSIONS:

In patients with type 2 diabetes, 6months liraglutide treatment was associated with a significant improvement in diastolic function.

• Authors: Fabio Saponaro, Andrea Sonaglioni, Antonio Rossi, Laura Montefusco, Michele Lombardo, Guido Adda, Maura Arosio
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 118 Pg. 21-8 (Aug 2016) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 27485853 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2016 The Author(s). Published by Elsevier Ireland Ltd.. All rights reserved.

Chemical References

• Hypoglycemic Agents
• Liraglutide

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Diabetes Mellitus, Type 2 (complications, drug therapy, physiopathology)
• Diabetic Cardiomyopathies (diagnosis, etiology, physiopathology)
• Diastole
• Drug Administration Schedule
• Echocardiography, Doppler
• Female
• Follow-Up Studies
• Heart Ventricles (diagnostic imaging, drug effects, physiopathology)
• Humans
• Hypoglycemic Agents (administration & dosage)
• Liraglutide (administration & dosage)
• Male
• Middle Aged
• Prospective Studies
• Ventricular Function, Left (drug effects)
• Young Adult