Adult-onset opsoclonus-myoclonus syndrome due to West Nile Virus treated with intravenous immunoglobulin.

Abstract

A 63-year-old female with no significant past medical history was presented with a 5-day history of progressive opsoclonus-myoclonus, headaches, and fevers. Her workup was significant only for positive West-Nile Virus serum serologies. She received a 2-day course of intravenous immunoglobulin (IvIG). At an 8-week follow up, she had a complete neurological remission. Adult-onset opsoclonus-myoclonus syndrome is a rare condition for which paraneoplastic and infectious causes have been attributed. To our knowledge, this is the first case reported of opsoclonus-myoclonus secondary to West-Nile Virus treated with intravenous immunoglobulin monotherapy.

• Authors: Julien Hébert, David Armstrong, Nick Daneman, Jennifer Deborah Jain, James Perry
• Journal: Journal of neurovirology (J Neurovirol) Vol. 23 Issue 1 Pg. 158-159 (02 2017) ISSN: 1538-2443 [Electronic] United States
• PMID: 27473195 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Female
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Middle Aged
• Opsoclonus-Myoclonus Syndrome (diagnosis, drug therapy, etiology, immunology)
• Treatment Outcome
• West Nile Fever (complications, diagnosis, drug therapy, immunology)
• West Nile virus (immunology, isolation & purification, pathogenicity)