Abstract | BACKGROUND:
Insulin resistance (IR), constitutes an important cardiovascular risk factor and can cause ischemic heart disease. It can lead to left ventricular dysfunction with a mechanism independent of ischemic heart disease and it is closely associated with impaired vascular function. The aim of our study was to explore the impact of IR on cardiac and vascular function, in patients with cardiovascular risk factors but angiographically undamaged coronary arteries. METHODS: RESULTS: The patients were divided into two groups based on the median value of HOMA-IR, the first group for values <4.14 and, the second, for values ≥4.14. Ejection fraction and diastolic function did not significantly differ between the two groups, whether in patients with higher levels of HOMA-IR (≥4.14) we observed a Global Longitudinal Strain (GLS) that was significantly reduced (-16.50±1.37% vs. -20.73±1.84%, p=0.0015) vascular stiffness, measured in the carotid arteries as pulse wave velocity (PWV) (9.70±1.75m/s vs. 7.40±1.89m/s, p=0.00148) that was increased. At multivariate analysis HOMA-IR was an independent predictor of myocardial dysfunction (GLS: coefficient 0.1156, p<0.0001). CONCLUSION:
Insulin resistance is associated with subclinical myocardial and vascular alterations in patients without significant coronary artery disease, measured as a reduction of Global Longitudinal Strain, and increased arterial stiffness. Our results underscore the importance of studying the interaction between ventricular function and vessels, in the perspective of more effective preventive and therapeutic interventions.
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Authors | Giuseppina Novo, Girolamo Manno, Rosario Russo, Dario Buccheri, Sonia Dell'Oglio, Pierluigi Morreale, Giovanna Evola, Giustina Vitale, Salvatore Novo |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 221
Pg. 1095-9
(Oct 15 2016)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 27448539
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
Topics |
- Aged
- Cardiovascular Diseases
(diagnosis, epidemiology)
- Carotid Arteries
(diagnostic imaging)
- Coronary Angiography
(methods)
- Echocardiography
(methods)
- Female
- Humans
- Insulin Resistance
(physiology)
- Italy
(epidemiology)
- Male
- Middle Aged
- Risk Assessment
(methods)
- Risk Factors
- Ultrasonography, Doppler
(methods)
- Vascular Stiffness
(physiology)
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