Disseminated Talaromyces marneffei and Mycobacterium abscessus in a Patient With Anti-Interferon-γ Autoantibodies.

Abstract

Anti-interferon (IFN)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. We report on disseminated Talaromyces (Penicillium) marneffei and Mycobacterium abscessus infection in a 72-year-old, human immunodeficiency virus noninfected, Thai man with anti-IFN-γ autoantibody. The patient was successfully treated with antimicrobial therapy and rituximab to control B cell-derived autoantibodies.

• Authors: Nattapol Pruetpongpun, Thana Khawcharoenporn, Pansachee Damronglerd, Worapop Suthiwartnarueput, Anucha Apisarnthanarak, Sasinuch Rujanavej, Nuntra Suwantarat
• Journal: Open forum infectious diseases (Open Forum Infect Dis) Vol. 3 Issue 2 Pg. ofw093 (Apr 2016) ISSN: 2328-8957 [Print] United States
• PMID: 27419165 (Publication Type: Journal Article)