Abstract |
Small-cell lung cancer (SCLC), initially exquisitely sensitive to first-line cisplatin/ etoposide, invariably relapses and acquires a multidrug chemoresistant phenotype that generally renders retreatment with first-line therapy both futile and counterproductive. This report presents the case of a 77-year-old Caucasian male with extensive-stage refractory SCLC who was restarted on platinum doublets as part of a clinical trial called TRIPLE THREAT (NCT02489903) involving pretreatment with the epi-immunotherapeutic agent RRx-001, and who achieved a partial response after only 4 cycles. The patient had received a platinum drug twice before, in 2009 for a diagnosis of non-small-cell lung cancer ( squamous cell carcinoma) and in 2015 for SCLC, suggesting that RRx-001 pretreatment may sensitize or resensitize refractory SCLC patients to first-line chemotherapy.
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Authors | Corey A Carter, Bryan Oronsky, Scott Caroen, Jan Scicinski, Aiste Degesys, Pedro Cabrales, Tony R Reid, Christina Brzezniak |
Journal | Case reports in oncology
(Case Rep Oncol)
2016 May-Aug
Vol. 9
Issue 2
Pg. 285-9
ISSN: 1662-6575 [Print] Switzerland |
PMID | 27403127
(Publication Type: Case Reports)
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