New Carbocyclic Amino Acid Derivatives Inhibit Infection Caused by Highly Pathogenic Influenza A Virus Strain (H5N1).

Abstract

New amino acid derivatives with carbocycles of adamantine and quinaldic acid were synthesized and their in vitro antiviral activity against influenza A/H5N1 virus was evaluated. Experiments on cultured embryonic porcine kidney epithelial cells showed that amino acid derivatives suppressed viral replication. Tret-butyloxycarbonyl-DL-methionylsulfonyl-1-adamantayl ethylamine and benzyloxycarbonyl-L-trypthophanyl-1-adamantayl ethylamine compounds demonstrated high activity in all in vitro experiments. Moreover, some compounds showed virucidal activity against influenza A/H5N1 virus.

• Authors: V A Shibnev, T M Garaev, P G Deryabin, M P Finogenova, A G Botikov, D V Mishin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 161 Issue 2 Pg. 284-7 (Jun 2016) ISSN: 1573-8221 [Electronic] United States
• PMID: 27383164 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Antiviral Agents
• Rimantadine

Topics

• Amino Acids (pharmacology)
• Animals
• Antiviral Agents (pharmacology)
• Cells, Cultured
• Drug Evaluation, Preclinical
• Influenza A Virus, H5N1 Subtype (drug effects, physiology)
• Inhibitory Concentration 50
• Rimantadine (pharmacology)
• Sus scrofa
• Virus Replication (drug effects)