Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis.

Abstract

Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.

• Authors: Matthias H Tschöp, Michael Stumvoll, Michael Ristow
• Journal: Cell metabolism (Cell Metab) Vol. 23 Issue 6 Pg. 959-960 (06 14 2016) ISSN: 1932-7420 [Electronic] United States
• PMID: 27304493 (Publication Type: Journal Article, Comment)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Hypoglycemic Agents
• Reactive Oxygen Species

Topics

• Animals
• Cell Proliferation (drug effects)
• Diabetes Mellitus, Type 2 (drug therapy, pathology)
• Humans
• Hypoglycemic Agents (pharmacology, therapeutic use)
• Mitochondria (drug effects, metabolism)
• Models, Biological
• Neoplasm Metastasis
• Neoplasms (drug therapy, pathology)
• Reactive Oxygen Species (metabolism)