High E/e' disrupts the rapid lowering of blood glucose in response to exercise training.

Abstract

BACKGROUND:

No relationship between the ratio of peak early velocity of left ventricular inflow to peak systolic longitudinal velocity of the mitral annulus velocity (E/e') and insulin resistance has yet been shown in patients with cardiac disease. We hypothesized that patients with high E/e' values would tend not to show the rapid blood glucose-lowering in response to exercise training characteristic of impaired glucose tolerance (IGT) or diabetes mellitus (DM) patients.

METHODS:

The subjects were continuous IGT/DM patients (n = 27) participating in cardiac rehabilitation. All patients' E/e' values were measured by echocardiography. The patients' blood glucose levels (mg/dl) were measured just before (pre-BS) and after (post-BS) exercise training. Post-BS was subtracted from pre-BS to obtain ΔBS, and the relationship between E/e' and ΔBS was investigated.

RESULTS:

E/e' correlated negatively with ΔBS. Moreover, E/e' was a significant predictor of ΔBS and as such was independent of hemoglobin A1c (HbA1c), pre-BS, and presence of atrial fibrillation on multivariate analysis.

CONCLUSIONS:

Patients with high E/e', indicating high left ventricular filling pressure, were unlikely to exhibit the rapid glucose-lowering response.

• Authors: Yamato Fukuda, Kumiko Yoshimura, Yoshiharu Fukuda, Nobuo Fukuda
• Journal: Journal of echocardiography (J Echocardiogr) Vol. 10 Issue 4 Pg. 119-24 (Dec 2012) ISSN: 1349-0222 [Print] Japan
• PMID: 27278346 (Publication Type: Journal Article)