The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses.

Abstract

Cytokines related to tumor necrosis factor (TNF) provide a communication network essential for coordinating multiple cell types into an effective host defense system against pathogens and malignant cells. The pathways controlled by the TNF superfamily differentiate both innate and adaptive immune cells and modulate stromal cells into microenvironments conducive to host defenses. Members of the TNF receptor superfamily activate diverse cellular functions from the production of type 1 interferons to the modulation of survival of antigen-activated T cells. Here, we focus attention on the subset of TNF superfamily receptors encoded in the immune response locus in chromosomal region 1p36. Recent studies have revealed that these receptors use diverse mechanisms to either co-stimulate or restrict immune responses. Translation of the fundamental mechanisms of TNF superfamily is leading to the design of therapeutics that can alter pathogenic processes in several autoimmune diseases or promote immunity to tumors.

• Authors: Lindsay K Ward-Kavanagh, Wai Wai Lin, John R Šedý, Carl F Ware
• Journal: Immunity (Immunity) Vol. 44 Issue 5 Pg. 1005-19 (05 17 2016) ISSN: 1097-4180 [Electronic] United States
• PMID: 27192566 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Receptors, Tumor Necrosis Factor

Topics

• Adaptive Immunity
• Animals
• Autoimmune Diseases (immunology)
• Chromosome Deletion
• Chromosome Disorders (genetics)
• Chromosomes, Human, Pair 1 (genetics)
• Humans
• Immunity, Innate
• Immunotherapy (methods, trends)
• Lymphocyte Activation
• Neoplasms (immunology)
• Neurogenesis (genetics)
• Receptor Cross-Talk
• Receptors, Tumor Necrosis Factor (metabolism)
• Signal Transduction
• T-Lymphocytes (immunology)