Overlap of IgG4-related Disease and Primary Biliary Cirrhosis Complicated with Autoimmune Thrombocytopenia.

Abstract

A 63-year-old woman was referred to Fukushima Red Cross Hospital with an enlargement of the left submandibular gland and subcutaneous bleeding in the chest and legs. A diffuse enlargement of the pancreas was also detected by abdominal computed tomography, and laboratory data showed severe thrombocytopenia. She was diagnosed with IgG4-related disease (IgG4-RD) complicated with autoimmune thrombocytopenia and was treated with methylprednisolone, after which the number of platelets favorably increased. Further investigation for liver dysfunction revealed underlying primary biliary cirrhosis (PBC). We herein report a rare case of IgG4-RD overlapping PBC complicated with autoimmune thrombocytopenia.

• Authors: Mika Takasumi, Masayuki Miyata, Masahito Kuroda, Kumiko Terashima, Kazumichi Abe, Atsushi Takahashi, Hiroko Kobayashi, Kazuhiro Tazaki, Hiroshi Watanabe, Hiromasa Ohira
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 55 Issue 10 Pg. 1387-92 ( 2016) ISSN: 1349-7235 [Electronic] Japan
• PMID: 27181554 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin G
• Methylprednisolone

Topics

• Female
• Humans
• Immunoglobulin G (blood)
• Liver Cirrhosis, Biliary (complications)
• Methylprednisolone (therapeutic use)
• Middle Aged
• Purpura, Thrombocytopenic, Idiopathic (complications, drug therapy)
• Submandibular Gland (pathology)
• Tomography, X-Ray Computed