Serum miR-1297: a promising diagnostic biomarker in esophageal squamous cell carcinoma.

Abstract

We aimed to value the diagnostic potential of serum miR-1297 in esophageal squamous cell cancer (ESCC). Its expression level was detected in 156 pairs of patients with ESCC and healthy volunteers using quantitative real-time polymerase chain reaction (qRT-PCR) method. It was statistically decreased in ESCC patients compared with healthy controls. AUC based on serum miR-1297 was 0.840 ± 0.035 in discovery group and 0.837 ± 0.034 in validation group. Further analysis on early-stage patients revealed that the AUC was 0.819 ± 0.053 in discovery group and 0.814 ± 0.044 in validation group. Its sensitivity and specificity were promising. In conclusion, serum miR-1297 can serve as an ideal indicator for the diagnosis of ESCC.

• Authors: Cong Wang, Qingbao Li, Fang Liu, Xuan Chen, Effat Un Nesa, Shanghui Guan, Bowen Liu, Lihui Han, Bingxu Tan, Ding Wang, Pengxiang Chen, Xiaoyue Liu, Han Zhang, Ying Sun, Yufeng Cheng
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 21 Issue 6 Pg. 517-22 (Sep 2016) ISSN: 1366-5804 [Electronic] England
• PMID: 27152453 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• MIRN1297 microRNA, human
• MicroRNAs

Topics

• Aged
• Biomarkers, Tumor (blood)
• Carcinoma, Squamous Cell (blood, diagnosis)
• Case-Control Studies
• Esophageal Neoplasms (blood, diagnosis)
• Female
• Humans
• Male
• MicroRNAs (blood)
• Middle Aged
• ROC Curve