HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Electroacupuncture Improves Insulin Resistance by Reducing Neuroprotein Y/Agouti-Related Protein Levels and Inhibiting Expression of Protein Tyrosine Phosphatase 1B in Diet-induced Obese Rats.

Abstract
Electroacupuncture (EA) has been shown to exert beneficial effects on obesity, but the mechanism is unclear. This study investigated the effects of EA on diet-induced obese (DIO) rats. Fifty male Sprague-Dawley rats were randomly divided into low-fat diet (LFD, 10 rats) and high-fat diet (HFD, 40 rats) groups. After the DIO models had been established, successful model rats were randomly divided into HFD, EA, and orlistat (OLST) groups. The EA group received EA at Zusanli (ST36) and Quchi (LI11) for 20 minutes once per day for 28 days. The OLST group was treated with orlistat by gavage. The body weight, homeostasis model assessment-insulin resistance index, adipocyte diameters, and neuroprotein Y/agouti-related protein and protein tyrosine phosphatase 1B levels were significantly lower in the EA group than in the HFD group. The rats of the OLST group showed watery stools and yellow hairs whereas those of the EA group had regular stools and sleek coats. The effect of EA on weight loss may be related to improved insulin resistance caused by changes in the adipocyte size and by reductions in the expressions of neuroprotein Y/agouti-related protein and protein tyrosine phosphatase 1B. This study indicates that EA may be a better method of alternative therapy for treating obesity and other metabolic diseases.
AuthorsXia Liu, Jun-Feng He, Ya-Ting Qu, Zhi-Jun Liu, Qing-Yang Pu, Sheng-Tong Guo, Jia Du, Peng-Fei Jiang
JournalJournal of acupuncture and meridian studies (J Acupunct Meridian Stud) Vol. 9 Issue 2 Pg. 58-64 (Apr 2016) ISSN: 2093-8152 [Electronic] Korea (South)
PMID27079226 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015. Published by Elsevier B.V.
Chemical References
  • Agouti-Related Protein
  • Blood Glucose
  • Insulin
  • Neuropeptide Y
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
Topics
  • Agouti-Related Protein (genetics, metabolism)
  • Animals
  • Blood Glucose (metabolism)
  • Diet, High-Fat (adverse effects)
  • Electroacupuncture
  • Female
  • Humans
  • Insulin (metabolism)
  • Insulin Resistance
  • Male
  • Neuropeptide Y (genetics, metabolism)
  • Obesity (enzymology, genetics, metabolism, therapy)
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 (genetics, metabolism)
  • Rats
  • Rats, Sprague-Dawley

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: