Abstract | OBJECTIVE: DATA SOURCES: PubMed, EMBASE, and the Cochrane Library. STUDY SELECTION: DATA EXTRACTION: Information on noble gas, organ, species, model, length of ischemia, conditioning and noble gas dose, duration of administration of the gas, endpoints, and effects was extracted from 79 eligible articles. Study quality was evaluated using the Jadad scale. Effect sizes were extracted from the articles or retrieved from the authors to allow meta-analyses using the random-effects approach. DATA SYNTHESIS: CONCLUSIONS:
Helium and xenon show organ protective effects mostly in small animal ischemia reperfusion injury models. Additional information on timing, dosing, and comparative efficacy of the different noble gases, as well as confirmation in large animal models, is needed before designing clinical trials.
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Authors | Julie De Deken, Steffen Rex, Diethard Monbaliu, Jacques Pirenne, Ina Jochmans |
Journal | Critical care medicine
(Crit Care Med)
Vol. 44
Issue 9
Pg. e886-96
(Sep 2016)
ISSN: 1530-0293 [Electronic] United States |
PMID | 27071065
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
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Topics |
- Animals
- Humans
- Noble Gases
(therapeutic use)
- Reperfusion Injury
(prevention & control)
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