Abstract | OBJECTIVES: We aimed to investigate whether prior use of antiplatelet agents (AP) may be associated with lower severity and improved short-term outcome of the first-ever acute ischaemic stroke. METHODS: RESULTS: During the study period, there were 3036 eligible patients, of whom 879 (29%) received AP before stroke onset. Patients from the AP group were older and more often burdened with stroke risk factors. There were no differences in baseline stroke severity, hospital mortality and proportion of patients alive and independent at discharge. However, AP turned out to be independently associated with lower NIHSS score on admission (β = -0.045, p = 0.008) and increased odds for being alive and independent at discharge (odds ratio 1.36, 95% CI: 1.13-1.67) and decreased odds for in-hospital mortality (odds ratio 0.77, 95% CI: 0.59-0.99). CONCLUSIONS: Our findings provide further evidence supporting modest benefit of AP therapy on the course and outcome of first-ever ischaemic stroke. Further large studies are needed to confirm this effect.
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Authors | J P Bembenek, M Niewada, M Karlinski, A Czlonkowska |
Journal | International journal of clinical practice
(Int J Clin Pract)
Vol. 70
Issue 6
Pg. 477-81
(Jun 2016)
ISSN: 1742-1241 [Electronic] India |
PMID | 27040605
(Publication Type: Journal Article)
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Copyright | © 2016 John Wiley & Sons Ltd. |
Chemical References |
- Platelet Aggregation Inhibitors
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Topics |
- Administration, Oral
- Age Factors
- Aged
- Aged, 80 and over
- Case-Control Studies
- Drug Administration Schedule
- Female
- Humans
- Male
- Platelet Aggregation Inhibitors
(administration & dosage, therapeutic use)
- Poland
(epidemiology)
- Registries
- Regression Analysis
- Retrospective Studies
- Risk Factors
- Severity of Illness Index
- Sex Factors
- Stroke
(epidemiology, physiopathology, prevention & control)
- Treatment Outcome
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