Protective effect of Geraniol on the transgenic Drosophila model of Parkinson's disease.

Abstract

The role of Geraniol was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons. Geraniol at final concentration of 10, 20 and 40μM were mixed in the diet and the flies were allowed to feed on it for 24 days. The effect of geraniol was studied on the climbing ability, activity pattern, lipid peroxidation, protein carbonyl, glutathione, dopamine content, and glutathione-S-transferase activity in the brains of transgenic Drosophila. The exposure of PD model flies to 10, 20 and 40μM of geraniol results in a significant delay in the loss of climbing ability (p<0.05), improved activity pattern reduced the oxidative stress (p<0.05) in the brains of transgenic Drosophila as compared to unexposed PD model flies. The results suggest that geraniol is potent in reducing the PD symptoms in transgenic Drosophila model of Parkinson's disease.

• Authors: Yasir Hasan Siddique, Falaq Naz, Smita Jyoti, Fahad Ali, Ambreen Fatima, Rahul, Saba Khanam
• Journal: Environmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 43 Pg. 225-31 (Apr 2016) ISSN: 1872-7077 [Electronic] Netherlands
• PMID: 27026137 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• Acyclic Monoterpenes
• Plant Extracts
• Protective Agents
• Terpenes
• geraniol

Topics

• Acyclic Monoterpenes
• Animals
• Animals, Genetically Modified
• Disease Models, Animal
• Drosophila
• Oxidative Stress
• Parkinson Disease (drug therapy)
• Plant Extracts (pharmacology, therapeutic use)
• Protective Agents (pharmacology, therapeutic use)
• Terpenes (pharmacology, therapeutic use)