Liver cancer is a
malignancy of the digestive system and has a high morbidity and mortality rate. Local intervention has become a viable option in identifying liver treatment. The aim of the present study was to analyze the clinical effects of treating
liver cancer in middle and advanced stages using ultrasound-guided percutaneous
ethanol injection (PEI) in
tumors combined with
radiofrequency ablation (RFA). A total of 100 patients with stage III-IV
liver cancers were selected to participate in the study. Patients were divided into groups. In group A, treatment was initiated with PEI and after 1-2 weeks RFA was applied while in group B treatment was initiated with RFA and after 1-2 weeks PEI was applied. Patients in group C received PEI and RFA simultaneously. The clinical effects in the 3 groups were compared after 6-month follow ups. The volume of
tumor ablation
necrosis in group A was significantly greater than that in the groups B and C, while the size was significantly smaller compared to groups B and C after ablation. For group A, the complete ablation rate was significantly higher than that in groups B and C, and the differences were statistically significant (P<0.05). Liver damage indices, including raising levels of
glutamic-pyruvic transaminase and total
bilirubin, were significantly decreased in group A (P<0.05). The survival rate in group A was also significantly higher than in groups B and C (P<0.05). In conclusion, for patients with
liver cancer in middle and advanced stages, the treatment method using PEI followed by RFA was more beneficial in terms of improving the
tumor ablation rate, alleviating liver damages and increasing survival rates.