Abstract | BACKGROUND: OBJECTIVES: The aim of the present study was to evaluate the effects of extract of Hypericum perforatum (EHP) on the serum lipid profile (TCH, TG, and LDL-CH), aminotransferase, alkaline phosphatase, and lipid peroxidation in hyperlipidemic rats. MATERIALS AND METHODS: Thirty-two male rats weighting 200 ± 10 g were randomly divided into four experimental groups: 1) control, 2) control + EHP, 3) hyperlipidemia, and 4) hyperlipidemia + EHP. The rats in the hyperlipidemic groups were fed a high-fat diet for 60 days, and EHP (300 mg/kg) was injected intraperitoneally for 2 weeks in the rats in the second and fourth groups. At the end of the experimental period, blood samples from each group were analyzed. RESULTS: CONCLUSIONS: EHP was able to both reduce LDL-CH and to significantly decrease markers of oxidative stress and lipid peroxidation induced by hyperlipidemia. Therefore, this herb, as a new pharmacological component, could be used to reduce certain blood lipids, lipid peroxidation, and aminotransferase markers.
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Authors | Mohammad Hassan Ghosian Moghaddam, Mehrdad Roghani, Maryam Maleki |
Journal | Research in cardiovascular medicine
(Res Cardiovasc Med)
Vol. 5
Issue 2
Pg. e31326
(May 2016)
ISSN: 2251-9572 [Print] India |
PMID | 26949689
(Publication Type: Journal Article)
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