The expression of plakoglobin is a potential prognostic biomarker for patients with surgically resected lung adenocarcinoma.

Abstract

PURPOSE:

This study aimed to explore the relationship between plakoglobin expression and clinical data in the patients with surgically resected lung adenocarcinoma.

RESULTS:

With follow-up of median 50.14 months, the average PFS and OS were 16.82 and 57.92 months, respectively. In 147 patients, recurrence or death was observed in 131 patients. According to the log-rank test, low plakoglobin expression was a significant predictor for favorable DFS (P=0.006) and OS (P=0.043). For the analyses within subgroups, high plakoglobin expression was an independent factor for reducing DFS in non-metastatic patients with resected lung adenocarcinoma (P < 0.05). Moreover, high plakoglobin expression was associated with poor DFS even receiving adjuvant chemotherapy (P =0.028) and with a shorter DFS (HR, 2.01, 95%CIs, 1.35 to 2.97, P=0.001) and OS (HR, 1.94, 95%CIs, 1.12 to 3.37, P=0.019).

PATIENTS AND METHODS:

The expression of plakoglobin in 147 primary tumor tissues was examined by using immunohistochemistry and clinical data were collected. The optimal cutoff value of immunoreactivity score (IRS) was calculated and used to divide all the patients into two groups: low-level group (IRS: 0-3, n=59) and high-level group (IRS: 4-12, n=88). Kaplan-Meier curves were applied to assess the plakoglobin expression and clinical variables. The univariate and multivariate Cox model analyses were performed to evaluate the effects of clinical factors and plakoglobin expression on disease-free survival (DFS) and overall survival (OS).

CONCLUSIONS:

High plakoglobin expression is an independent negative prognostic factor for patients with surgically resected lung adenocarcinoma.

• Authors: Xiaobo He, Ting Zhou, Guangwei Yang, Wenfeng Fang, Zelei Li, Jianhua Zhan, Yuanyuan Zhao, Zhibin Cheng, Yan Huang, Hongyun Zhao, Li Zhang
• Journal: Oncotarget (Oncotarget) Vol. 7 Issue 12 Pg. 15274-87 (Mar 22 2016) ISSN: 1949-2553 [Electronic] United States
• PMID: 26933815 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• JUP protein, human
• gamma Catenin

Topics

• Adenocarcinoma (metabolism, pathology, surgery)
• Biomarkers, Tumor (metabolism)
• Carcinoma, Non-Small-Cell Lung (metabolism, pathology, surgery)
• Female
• Follow-Up Studies
• Humans
• Lung Neoplasms (metabolism, pathology, surgery)
• Male
• Middle Aged
• Prognosis
• Retrospective Studies
• Survival Rate
• gamma Catenin (metabolism)