Nε-(carboxymethyl)-lysine, White Matter, and Cognitive Function in Diabetes Patients.

Abstract

OBJECTIVE:

To study the relationship of Nε-(carboxymethyl)-lysine level (CML) with microstructure changes of white matter (WM), and cognitive impairment in patients with type 2 diabetes mellitus (T2DM) and to discuss the potential mechanism underlying T2DM-associated cognitive impairment.

METHODS:

The study was performed in T2DM patients (n=22) with disease course ≥5 years and age ranging from 65 to 75 years old. A control group consisted of 25 sex- and age-matched healthy volunteers. Fractional anisotropy (FA) of several WM regions was analyzed by diffusion tensor imaging scan. Plasma CML levels were measured by enzyme-linked immunosorbent assay, and cognitive function was assessed by Mini-Mental State Examination and Montreal cognitive assessment (MoCA).

RESULTS:

The total Mini-Mental State Examination score in the patient group (25.72±3.13) was significantly lower than the control group (28.16±2.45) (p<0.05). In addition, the total MoCA score in the patient group (22.15±3.56) was significantly lower than the control group 25.63±4.12) (p<0.01). In the patient group, FA values were significantly decreased in the corpus callosum, cingulate fasciculus, inferior fronto-occipital fasciculus, parietal WM, hippocampus, and temporal lobes relative to corresponding regions of healthy controls (p<0.05). Plasma CML level was negatively correlated with average FA values in the global brain (r=-0.58, p<0.01) and MoCA scores (r=-0.47, p<0.05).

CONCLUSIONS:

In T2DM, WM microstructure changes occur in older patients, and elevations in CML may play a role in the development of cognitive impairment.

• Authors: Jian-Hui Zhang, Hong-Zeng Xu, Qi-Feng Shen, Yong-Zhong Lin, Chang-Kai Sun, Lin Sha, Yu-Song Ge, Ying Liu, Chun Wang
• Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (Can J Neurol Sci) Vol. 43 Issue 4 Pg. 518-22 (Jul 2016) ISSN: 0317-1671 [Print] England
• PMID: 26889714 (Publication Type: Journal Article)

Chemical References

• N(6)-carboxymethyllysine
• Lysine

Topics

• Aged
• Anisotropy
• Case-Control Studies
• Cognition Disorders (diagnostic imaging, etiology)
• Diabetes Mellitus, Type 2 (blood, complications, diagnostic imaging)
• Diffusion Magnetic Resonance Imaging
• Female
• Humans
• Image Processing, Computer-Assisted
• Leukoencephalopathies (diagnostic imaging, etiology)
• Lysine (analogs & derivatives, blood)
• Male
• Mental Status Schedule
• Neuropsychological Tests