An Overview of Non-Neural Sources of Calcitonin Gene-Related Peptide.

Abstract

Calcitonin gene-related peptide (CGRP) is extensively distributed throughout the central and peripheral nervous systems and has been shown to be a 37 amino acid multifunctional neuropeptide involved in a wide range of physiological and pathological processes. Recently, there is increasing evidence suggesting that CGRP also exists in non-nerve cells, such as epithelial cells, endothelial cells, endothelial progenitor cells (EPCs), T lymphocytes, B lymphocytes, peripheral blood mononuclear cells (PBMCs), and adipocytes. The existence of CGRP in non-neural tissue is of great importance to the regulation of multiple physiological and pathological processes via different pathways, especially through an autocrine/paracrine mode. This review integrates evidence from recent developments and aims to provide novel insights into non-neural sources of CGRP and its effects on physiological and pathological processes.

• Authors: Rong Hu, Yuan-Jian Li, Xiao-Hui Li
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 23 Issue 8 Pg. 763-73 ( 2016) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 26861004 (Publication Type: Journal Article, Review)

Chemical References

• Calcitonin Gene-Related Peptide

Topics

• Calcitonin Gene-Related Peptide (metabolism)
• Endothelial Cells (metabolism)
• Epithelial Cells (metabolism)
• Humans
• Lymphocytes (metabolism)