The use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology.

Abstract

We analyzed publications and articles in the PubMed database about the use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology. Literature published in the English language, at least in the past two decades, was reviewed. Specific dermatologic indications for TMP-SMX are few but it is often used as the second- or third- line agent. TMP-SMX is used to treat cutaneous nocardiosis and Aeromonas infections. TMP-SMX is a treatment option for cat - scratch disease, granuloma inguinale, melioidosis and Mycobacterium marinum/fortuitum cutaneous infections. TMP-SMX is an alternate choice for treatment of pyodermas and lymphogranuloma venereum. TMP-SMX has been used to treat acne vulgaris in tetracycline and erythromycin - resistant patients. TMP-SMX is still the preferred empiric antibiotic for methicillin - resistant Staphylococcus aureus skin and soft tissue infection in HIV positive population. TMP-SMX is used in dermatology to treat various skin conditions and is one of the most commonly prescribed sulfonamide drugs. TMP-SMX as monotherapy is an effective treatment option in many diseases but due to drug resistance, a combination therapy-usually of two drugs-may be considered.

• Authors: Karolina Michałek, Marta Lechowicz, Maciej Pastuszczak, Anna Wojas-Pelc
• Journal: Folia medica Cracoviensia (Folia Med Cracov) Vol. 55 Issue 1 Pg. 35-41 ( 2015) ISSN: 0015-5616 [Print] Poland
• PMID: 26774630 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Infective Agents
• Trimethoprim, Sulfamethoxazole Drug Combination

Topics

• Anti-Infective Agents (pharmacology, therapeutic use)
• Clinical Trials as Topic
• Dose-Response Relationship, Drug
• Humans
• Methicillin-Resistant Staphylococcus aureus (drug effects)
• Soft Tissue Infections (drug therapy, prevention & control)
• Staphylococcal Infections (drug therapy, prevention & control)
• Trimethoprim, Sulfamethoxazole Drug Combination (pharmacology, therapeutic use)