Adaptation to acute coronary syndrome-induced stress with lowering of testosterone: a possible survival factor.

Abstract

OBJECTIVE:

The objective of this study was to explore whether circulating testosterone (T) concentration is associated with the occurrence and risk for acute coronary syndromes (ACS).

METHOD:

This case-control study included male patients with acute myocardial infarction (AMI) (n=174) or unstable angina pectoris (UAP) (n=90) and healthy controls (n=238). Patients gave serum samples during the acute (n=264) and recovery (n=132) phases after a median of 10.5 months after the incident event. Secondary events (ACS or cardiovascular death) were registered during the following 6 years.

RESULTS:

During the acute phase, AMI and UAP patients had similar significantly reduced concentrations of serum testosterone in comparison to controls. Testosterone associated inversely with weight, the degree of inflammation (i.e. C-reactive protein concentration) and signs of a chronic infection. In a multiadjusted Cox regression, when compared to testosterone concentrations considered high-normal (14.91-34.0  nmol/l), low-normal testosterone (9.26-14.90  nmol/l) in the acute phase predicted better prognosis for cardiovascular death rate with a hazard ratio (HR) of 0.17 (0.04-0.68, P=0.012). The increased testosterone concentrations after the recovery period did not associate with future cardiovascular disease events.

CONCLUSION:

Low-normal testosterone levels in the acute phase of ACS predicted better survival. The observation may indicate better adaptation to stress in survivors and warrants further study.

• Authors: Erkki Pesonen, Pirkko Pussinen, Ilpo Huhtaniemi
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 174 Issue 4 Pg. 481-9 (Apr 2016) ISSN: 1479-683X [Electronic] England
• PMID: 26772984 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 European Society of Endocrinology.

Chemical References

• Testosterone

Topics

• Acute Coronary Syndrome (blood, metabolism, mortality)
• Adaptation, Physiological (physiology)
• Aged
• Angina, Unstable (blood, metabolism)
• Case-Control Studies
• Humans
• Male
• Middle Aged
• Myocardial Infarction (blood, metabolism)
• Risk Factors
• Stress, Physiological (physiology)
• Survival Rate
• Testosterone (blood)