Anticolitis activity of Chinese herbal formula yupingfeng powder via regulating colonic enterochromaffin cells and serotonin.
Abstract | OBJECTIVE: To investigate whether traditional Chinese herbal formula Yupingfeng (YPF) powder has an anti-inflammatory effect on colonic inflammation, and to explore the mechanism involved. MATERIALS AND METHODS: RESULTS: The results showed that the body weight of colitis mice was markedly decreased by 10, 12, 14, and 17% at 1, 3, 5, and 7 days (P < 0.05), whereas stool consistency score (3.6 vs. 0.4, P < 0.05), histopathological score (3.6 vs. 0.3, P < 0.05), and MPO activity (2.7 vs. 0.1, P < 0.05) in colitis mice were significantly increased compared to that of the normal mice; YPF powder treatment dose-dependently increased the body weight (7-13% increase) and decreased the stool consistency score (0.4-1.4 decrease), histopathological score (0.2-0.7 decrease), and MPO activity (0.1-0.9 decrease) in colitis mice. Colonic EC cell density (70% increase) and 5-HT content (40% increase) were markedly increased in colitis mice (P < 0.05), YPF powder treatment dose-dependently reduced EC cell density (20-50% decrease), and 5-HT content (5-27% decrease) in colitis mice. CONCLUSION: The findings demonstrate that the anti-inflammatory effect of YPF powder on TNBS - induced colitis may be mediated via reducing EC cell hyperplasia and 5-HT content. The important role of YPF powder in regulating colonic EC cell number and 5-HT content may provide an alternative therapy for colonic inflammation.
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Authors | Kai-hong Zang, Zhi Rao, Guo-qiang Zhang, Hong-yan Qin |
Journal | Indian journal of pharmacology
(Indian J Pharmacol)
2015 Nov-Dec
Vol. 47
Issue 6
Pg. 632-7
ISSN: 1998-3751 [Electronic] India |
PMID | 26729955
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Drugs, Chinese Herbal
- Gastrointestinal Agents
- Powders
- Serotonin Antagonists
- yupingfeng
- Serotonin
- Peroxidase
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Colitis
(drug therapy, immunology, metabolism, pathology)
- Colon
(drug effects, immunology, metabolism, pathology)
- Diarrhea
(etiology, physiopathology, prevention & control)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
(administration & dosage, therapeutic use)
- Enterochromaffin Cells
(drug effects, immunology, metabolism, pathology)
- Gastrointestinal Agents
(administration & dosage, therapeutic use)
- Hyperplasia
- Male
- Mice, Inbred BALB C
- Peroxidase
(antagonists & inhibitors, metabolism)
- Powders
- Random Allocation
- Serotonin
(chemistry, metabolism)
- Serotonin Antagonists
(administration & dosage, therapeutic use)
- Thinness
(etiology, prevention & control)
- Weight Gain
(drug effects)
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