Precision Medicine: Clarity for the Complexity of Dementia.

Abstract

Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

• Authors: Brenna Cholerton, Eric B Larson, Joseph F Quinn, Cyrus P Zabetian, Ignacio F Mata, C Dirk Keene, Margaret Flanagan, Paul K Crane, Thomas J Grabowski, Kathleen S Montine, Thomas J Montine
• Journal: The American journal of pathology (Am J Pathol) Vol. 186 Issue 3 Pg. 500-6 (Mar 2016) ISSN: 1525-2191 [Electronic] United States
• PMID: 26724389 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
• Copyright: Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Topics

• Alzheimer Disease (genetics, physiopathology, therapy)
• Cognition Disorders (genetics, physiopathology)
• Dementia (genetics, physiopathology)
• Humans
• Mutation
• Parkinson Disease (genetics, physiopathology, therapy)
• Precision Medicine