Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia.

Abstract

BACKGROUND:

Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients.

OBJECTIVE:

To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND).

METHODS:

One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used.

RESULTS:

FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15).

CONCLUSION:

FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.

• Authors: Pariya L Fazeli, David J Moore, Donald R Franklin, Anya Umlauf, Robert K Heaton, Ann C Collier, Christina M Marra, David B Clifford, Benjamin B Gelman, Ned C Sacktor, Susan Morgello, David M Simpson, John A McCutchan, Igor Grant, Scott L Letendre
• Journal: Current HIV research (Curr HIV Res) Vol. 14 Issue 4 Pg. 324-30 ( 2016) ISSN: 1873-4251 [Electronic] Netherlands
• PMID: 26673902 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Amyloid beta-Peptides

Topics

• AIDS Dementia Complex (pathology)
• Adult
• Amyloid beta-Peptides (analysis)
• Cerebrospinal Fluid (chemistry)
• Cross-Sectional Studies
• Dementia (pathology)
• Female
• HIV Infections (complications)
• Humans
• Male
• Middle Aged