Abstract | BACKGROUND: The aim of this study was to report the emergence of linezolid-resistant coagulase-negative staphylococci (CoNS) in an intensive care unit. METHODS: An observational study was conducted in critically ill patients with colonization or infection by linezolid-resistant CoNS between January 2010 and December 2014. We analyzed the epidemiological and clinical features, and the mechanism of resistance to linezolid. We also evaluated the association between the incidence of linezolid-resistant CoNS strains and the consumption of linezolid in the study period. RESULTS: During the study period 49 patients had a linezolid-resistant CoNS strain isolated from clinical samples (blood in 42 cases, urine in 6, peritoneal fluid in 1). Molecular study showed a combination of mechanisms of resistance. Most patients were critically ill (APACHE II score = 21.9 ± 8.3) and nearly all had undergone surgery and invasive procedures, and had prior exposure to antibiotics. Linezolid-resistant CoNS were considered to be contaminants in 42 patients and associated with infection in 7 patients, comprising bacteremia and septic shock in most of them. They were successfully treated with glycopeptides or daptomycin. A modest significant correlation was observed between the decrease in linezolid consumption and the lower incidence of resistant isolates. CONCLUSIONS:
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Authors | Bárbara Balandin, Beatriz Lobo, Beatriz Orden, Federico Román, Elena García, Rocío Martínez, Miguel Valdivia, Alfonso Ortega, Inmaculada Fernández, Pedro Galdos |
Journal | Infectious diseases (London, England)
(Infect Dis (Lond))
Vol. 48
Issue 5
Pg. 343-9
( 2016)
ISSN: 2374-4243 [Electronic] England |
PMID | 26670684
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Linezolid
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Topics |
- Aged
- Anti-Bacterial Agents
(pharmacology)
- Bacteremia
(epidemiology, microbiology)
- Drug Resistance, Bacterial
(genetics)
- Female
- Humans
- Intensive Care Units
(statistics & numerical data)
- Linezolid
(pharmacology)
- Male
- Middle Aged
- Retrospective Studies
- Staphylococcal Infections
(epidemiology, microbiology)
- Staphylococcus
(drug effects, genetics, isolation & purification)
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