Post-bronchiolitis Use of Asthma Medication: A Prospective 1-year Follow-up Study.

Abstract

BACKGROUND:

Our aim was to evaluate the association between viral findings during bronchiolitis and the use of asthma controller medication (primary outcome) and systemic corticosteroids (secondary outcome) during the first post-bronchiolitis year.

METHODS:

We enrolled 408 children hospitalized for bronchiolitis at <24 months of age in a prospective, 3-center, 1-year follow-up study in Finland. Viruses were detected with polymerase chain reaction in nasopharyngeal aspirates. The parents underwent a structured interview during hospitalization. Twelve months later, the use of asthma medication was asked in a structured questionnaire. Multivariable logistic regression was used for statistical analysis.

RESULTS:

In total, 365 (89%) children completed the 1-year follow-up. The use of long-term asthma controller medication was highest in the rhinovirus-positive group (61% vs. 15% in respiratory syncytial virus-positive group; adjusted odd ratios, 7.5; 95% confidence interval: 3.7-15.3), followed by children negative for both respiratory syncytial virus and rhinovirus (36%; adjusted odd ratios, 2.6; 95% confidence interval: 1.3-5.3). Likewise, rhinovirus etiology was associated with more courses of systemic corticosteroids during the follow-up. The main findings were similar in a subset of infants aged <12 months with first wheezing.

CONCLUSIONS:

Children hospitalized for rhinovirus-positive bronchiolitis used long-term asthma controller medication more often than those hospitalized for rhinovirus-negative bronchiolitis during first year after hospitalization.

• Authors: Eija Bergroth, Matilda Aakula, Matti Korppi, Sami Remes, Juho E Kivistö, Pedro A Piedra, Carlos A Camargo Jr, Tuomas Jartti
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 35 Issue 4 Pg. 363-8 (Apr 2016) ISSN: 1532-0987 [Electronic] United States
• PMID: 26658529 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Asthmatic Agents

Topics

• Anti-Asthmatic Agents (therapeutic use)
• Asthma (complications, drug therapy, epidemiology)
• Bronchiolitis (complications, epidemiology, virology)
• Child, Preschool
• Female
• Finland
• Follow-Up Studies
• Hospitalization
• Humans
• Infant
• Infant, Newborn
• Male
• Odds Ratio
• Risk Factors
• Surveys and Questionnaires
• Treatment Outcome
• Virus Diseases (complications, virology)