Nadolol antihypertensive effect and disposition in young and elderly adults with mild to moderate essential hypertension.

Abstract

Nadolol was effective and well tolerated as once-daily monotherapy for mild to moderate essential supine diastolic hypertension (SDBP) in 10 young (mean age, 39 years) and 12 elderly (mean age, 68 years) patients in a single-blind, placebo-baseline, escalating-dose study. Doses required to reduce SDBP to 90 mm Hg were not different in young (1.08 +/- 0.21 mg/kg/day) and elderly (0.82 +/- 0.14 mg/kg/day) patients (mean +/- SE). Trough plasma nadolol concentrations at steady state were similar and were linearly related to dose in both groups. More unchanged nadolol was recovered in 24-hour urine samples from young subjects (15.6% +/- 1.9%) than from elderly ones (10.7% +/- 1.1%) (p = 0.028). With increasing nadolol doses, plasma norepinephrine concentration increased and isoproterenol sensitivity decreased in both young and elderly subjects, and creatinine clearance and plasma active renin levels were unchanged; plasma inactive renin levels increased in the young, and aldosterone concentration declined in the elderly with the lowest nadolol dose.

• Authors: P A Mitenko, J K McKenzie, D S Sitar, S B Penner, F Y Aoki
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 46 Issue 1 Pg. 56-62 (Jul 1989) ISSN: 0009-9236 [Print] United States
• PMID: 2663317 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nadolol
• Aldosterone
• Creatinine
• Renin
• Norepinephrine

Topics

• Adult
• Aged
• Aging (metabolism)
• Aldosterone (blood)
• Creatinine (metabolism)
• Dose-Response Relationship, Drug
• Female
• Humans
• Hypertension (drug therapy)
• Infusions, Intravenous
• Male
• Middle Aged
• Nadolol (administration & dosage, pharmacokinetics, pharmacology)
• Norepinephrine (blood)
• Renin (blood)