Mechanisms of Aeroallergen Immunotherapy: Subcutaneous Immunotherapy and Sublingual Immunotherapy.

Abstract

Allergen immunotherapy (AIT) is an effective way to treat allergic disorders, targeting the underlying mechanisms and altering the disease course by inducing a long-lasting clinical and immune tolerance to allergens. Although sublingual and subcutaneous routes are used in daily practice, many novel ways to decrease side effects and duration and increase efficacy have been pursued. Further studies are needed to develop biomarkers for the identification of AIT responder patients and also to use the developed knowledge in allergy prevention studies. Future directions in AIT include treatments for autoimmune diseases, chronic infections, organ transplantation, and breaking immune tolerance to cancer cells.

• Authors: Cevdet Ozdemir, Umut Can Kucuksezer, Mübeccel Akdis, Cezmi A Akdis
• Journal: Immunology and allergy clinics of North America (Immunol Allergy Clin North Am) Vol. 36 Issue 1 Pg. 71-86 (Feb 2016) ISSN: 1557-8607 [Electronic] United States
• PMID: 26617228 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Air Pollutants
• Allergens

Topics

• Administration, Sublingual
• Air Pollutants (immunology)
• Allergens (immunology)
• Animals
• Desensitization, Immunologic
• Environmental Exposure (adverse effects)
• Humans
• Hypersensitivity (immunology, therapy)
• Immune Tolerance
• Injections, Subcutaneous
• T-Lymphocytes, Regulatory (immunology)