Abstract | PURPOSE: MATERIALS AND METHODS: Using direct sequencing, we investigated the association between functional polymorphisms of IL-18 and IL-18R genes and susceptibility to PTC in 94 PTC patients and 260 healthy controls. Genetic data were analyzed using commercially available software. Multiple logistic regression models were used to calculate odds ratios, 95% confidence intervals, and P-values for the association between the genotypes and risk of PTC. The PTC patients were further subgrouped and compared with respect to their clinicopathological characteristics. RESULTS: 3 SNPs of IL-18 (rs549908, rs360717, and rs187238) and one of IL-18R (rs1420106) examined in this study were significantly associated with the development of PTC. The allelic frequencies of the 3 SNPs of IL-18 also showed significant association with lymph node metastasis. CONCLUSION:
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Authors | J H Chung, Y C Lee, Y G Eun, J H Chung, S K Kim, S Chon, S J Oh, S Y Rhee, I K Hong |
Journal | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
(Exp Clin Endocrinol Diabetes)
Vol. 123
Issue 10
Pg. 598-603
(Nov 2015)
ISSN: 1439-3646 [Electronic] Germany |
PMID | 26600055
(Publication Type: Clinical Trial, Journal Article)
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Copyright | © Georg Thieme Verlag KG Stuttgart · New York. |
Chemical References |
- IL18 protein, human
- IL18R1 protein, human
- Interleukin-18
- Interleukin-18 Receptor alpha Subunit
- Neoplasm Proteins
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Topics |
- Adult
- Aged
- Carcinoma
(genetics)
- Carcinoma, Papillary
- Female
- Humans
- Interleukin-18
(genetics)
- Interleukin-18 Receptor alpha Subunit
(genetics)
- Lymphatic Metastasis
(genetics)
- Male
- Middle Aged
- Neoplasm Proteins
(genetics)
- Polymorphism, Single Nucleotide
- Thyroid Cancer, Papillary
- Thyroid Neoplasms
(genetics)
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